bioRxiv Preprint
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Phase: In Vivo (Murine)
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1 hour ago
Epigenetic Age Reversal in Skeletal Muscle via Non-Viral Yamanaka OSK Delivery
Stanford-led team demonstrates 42% restoration of muscle regenerative capacity in 24-month-old mice using lipid nanoparticles targeted to satellite cells. Horvath DNA methylation clocks registered a 31% reduction in biological tissue age without teratoma formation.
Nature Biotechnology
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Phase: In Vitro / Machine Learning
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3 hours ago
AlphaFold-Genomics Predicts De Novo Peptide Senolytics Targeting BCL-xL
Computational screening of over 1.4 million peptide conformations yields three high-affinity candidates that selectively trigger apoptosis in senescent endothelial cells with 8.4x higher selectivity over navitoclax, drastically minimizing platelet toxicity.